Flamitrol is indicated in ocular inflammation when concurrent use of an antimicrobial is judged necessary.

DOSAGE & ADMINISTRATION Eye drops: One drop topically into the conjunctival sac(s). In severe disease, drops may be used hourly, being tapered to discontinuation as the inflammation subsides. In mild disease, drops may be used up to four to six times daily. SIDE-EFFECTS Adverse reactions have occurred with steroid/anti-infective combination drugs which can be attributed to the steroid component, the anti-infective component, or the combination. Exact incidence figures are not available since no denominator of treated patients is available. Reactions occurring most often from the presence of the anti-infective ingredient are allergic sensitizations. The reactions due to the steroid component in decreasing order of frequency are: elevation of intraocular pressure (IOP) with possible development of glaucoma, and infrequent optic nerve damage, posterior sub-capsular cataract formation and delayed wound healing. CONTRAINDICATIONS Epithelial herpes simplex keratitis (dentritic keratitis), vaccinia, varicella, and many other viral diseases of the cornea and conjunctiva. Hypersensitivity to a component of the medication (Hypersensitivity to the antibiotic component occurs at a higher rate than other component). The use of these combinations is always contraindicated after uncomplicated removal of a corneal foreign body. PRECAUTION & WARNING Prolonged use should be avoided as it may lead to skin sensitisation and emergency of resistant organisms. Because of risk of steriod glaucoma and cataract formation, the intraocular pressure and lens must be checked frequently during use of the preparation. USE IN PREGNANCY & LACTATION Pregnancy Category C. Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks. Unknown if excreted in breast milk; minimal systemic absorption with ophthalmic administration STORAGE • Store below 30 o C temperature in a dry place, protect from light • Do not use for longer than 30 days after first opening • Keep out of the reach of children